Research Interests

Miller is interested in analytical chemistry; specifically single-molecule based quantitative bioassays. Using this technique, she is able measure chemical reactions, the amount of product and reactants, between target molecules (proteins) and probe molecules (antibodies, aptamers).

Selected Publications

   
• A.E. Miller, C.W. Hollars, S. Lane, R.J. Saykally, T. Laurence “Characterization of Fluorescence Cross Correlation Spectroscopy as a universal detection method”  Analytical Chemistry 2009, 81 (14), 5614-5622
   
•                 A.E. Miller, A.J. Fischer, T. Laurence, C.W. Hollars, R.J. Saykally, J.C. Lagarias, and T. Huser, "Single-molecule dynamics of phytochrome-bound fluorophores probed by fluorescence correlation spectroscopy," PNAS 103, 11136-11141(2006)
   
•                 K.P. Knutsen, J.C. Johnson, A.E. Miller, P.B. Petersen, and R.J. Saykally, “High spectral resolution multiplex CARS spectroscopy using chirped pulses,” Proceedings of SPIE Conferences, Photonics West BiOS 2004, Proc. of SPIE Vol. 5323, p. 230-239, Multiphoton Microscopy in the Biomedical Sciences IV; A. Periasamy, P.T.C. So; Eds. (June 2004).
   
•                 O.L. Sydora, J.I. Goldsmith, T.P. Vaid, A.E. Miller, P.T.  Wolczanski, "Syntheses and Electrochemistry of (p-XC6H4O)6W (1-X, X = H, CH3, OCH3, Cl, Br, OH, OCH2Ph) and (p-X C6H4O)5W(O C6H4OH) (6-X, X = H, CH3, OCH3, Cl, Br): An Approach to Electrocatalytic CH Bond Activation."  Polyhedron 2004, 22, 2841-2856.
   
•                 K.P. Knutsen, J.C. Johnson, A.E. Miller, P.B. Petersen and R.J. Saykally, “High spectral resolution multiplex CARS spectroscopy using chirped pulses,” Chem. Phys. Lett. 387, 436-441 (2004)
   
•                 B.L. Weeks, A. Noy, A.E. Miller, J.E. Klare, B.W. Woods, and J.J. De Yoreo, "Dip-Pen Nanolithography using MHA and Optical Inks," Dekker Encyclopedia of Nanoscience and Nanotechnology, Marcel Dekker, 923-931 (2003)
   
•                 B.L. Weeks, J. Camarero, A. Noy, A.E. Miller, L. Stanker and J.J. De Yoreo. “A Microcantilever-Based Pathogen Detector” Scanning 25, 297-299 (2003) A. Noy, A.E. Miller, J.E. Klare, B.L. Weeks, B.W. Woods, and J.J. De Yoreo "Fabrication and imaging of luminescent nanostructures and polymer nanowires using dip-pen nanolithography" Nano Letters 2(2)  09-112 (2002)
   
•                 B.L. Weeks, A. Noy, A.E. Miller, and J.J. De Yoreo. The effect of dissolution kinetics on feature size in dip-pen nanolithography. Phys. Rev. Lett., 88, 255505 (2002). Also in Virtual Journal of Nanoscale Science & Technology, June 24, 2002.

Honors, Awards, and Fellowships

   
• National Research Council Postdoctoral Fellowship
   
• Lawrence Livermore Nat. Lab Student-Employee Graduate Research Fellowship

Professional Presentations

   
• A. E. Miller “Prion Aptamers, Free and Bound States” Biophysical Society Meeting, San Francisco, CA (February 2010) (poster)
   
• A. E. Miller  “Aptamer Dynamics” Division of Physical Chemistry 238nd ACS National Meeting – Washington DC (August 2009) (poster)
   
• A. E. Miller “ Aptamer Dynamics” Sigma Xi Postdoctoral Posters, Gaithersburg, MD February 2009 (poster)
   
• A. E. Miller “Single Molecule Analysis of PrP Aggregation” Single Molecule Approaches to Biology, Gordon Conference, New London, NH, August 2008 (poster)
   
• A. E. Miller “Applications of Optical Spectroscopy to the Study of Protein Aggregation” Physics Laboratory, NIST, Gaithersburg, MD October 29, 2007
   
• A. E. Miller “Applications of Optical Spectroscopy to the Study of Protein Aggregation” Georgia Tech, Atlanta, GA October 1, 2007
   
• A.E. Miller “Investigating beta amyloid 1-16 at the air-water interface and beyond”  T. Head Gordon Group, UC-Berkeley, Berkeley, CA September 12, 2007
   
• A.E. Miller* P.B. Petersen, C. W. Hollars, and R. J. Saykally “ Investigating beta amyloid 1-16 at the air-water interface” Division of Physical Chemistry 234nd ACS National Meeting – Boston, MA (August 19-23, 2007)  (poster)
   
• A.E. Miller “Application of Fluorescence Correlation Spectroscopy to Protein aggregation” Biophysics Seminar, Department of Physics, University of Illinois, Urban-Champaign, Urbana, IL February 16, 2007
   
• A.E. Miller*, T. Laurence, R.J. Saykally, and C.W. Hollars “Locating Proteins in Solution via Fluorescence Cross Correlation Spectroscopy” Center for Analytical Biotechnology, Berkeley, CA December 8, 2006 (presentation)