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Abigail Miller

Assistant Professor
Department of Chemistry

  • Abigail Miller received a PhD from the University of California, Berkeley, where she worked jointly with Rich Saykally’s group and the Biophotonics group at Lawrence Livermore National Laboratory, using optical spectroscopy to study protein aggregation. She then moved to the National Institute of Standards & Technology to study aptamer dynamics using single
    molecule based FRET with the Biophysics group. Her research interests as an undergraduate ranged from protein structure to organometallic synthesis to surface modification via atomic force microscopy.
  • Degrees

    PhD, Chemistry, University of California, Berkeley
    BA, Chemistry, Cornell University

  • CAS - Chemistry
  • Beeghly - 210

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Scholarly, Creative & Professional Activities

Research Interests

Miller is interested in analytical chemistry; specifically single-molecule based quantitative bioassays. Using this technique, she is able measure chemical reactions, the amount of product and reactants, between target molecules (proteins) and probe molecules (antibodies, aptamers).

Selected Publications

  • A.E. Miller, C.W. Hollars, S. Lane, R.J. Saykally, T. Laurence “Characterization of Fluorescence Cross Correlation Spectroscopy as a universal detection method”  Analytical Chemistry 2009, 81 (14), 5614-5622
  •                 A.E. Miller, A.J. Fischer, T. Laurence, C.W. Hollars, R.J. Saykally, J.C. Lagarias, and T. Huser, "Single-molecule dynamics of phytochrome-bound fluorophores probed by fluorescence correlation spectroscopy," PNAS 103, 11136-11141(2006)
  •                 K.P. Knutsen, J.C. Johnson, A.E. Miller, P.B. Petersen, and R.J. Saykally, “High spectral resolution multiplex CARS spectroscopy using chirped pulses,” Proceedings of SPIE Conferences, Photonics West BiOS 2004, Proc. of SPIE Vol. 5323, p. 230-239, Multiphoton Microscopy in the Biomedical Sciences IV; A. Periasamy, P.T.C. So; Eds. (June 2004).
  •                 O.L. Sydora, J.I. Goldsmith, T.P. Vaid, A.E. Miller, P.T.  Wolczanski, "Syntheses and Electrochemistry of (p-XC6H4O)6W (1-X, X = H, CH3, OCH3, Cl, Br, OH, OCH2Ph) and (p-X C6H4O)5W(O C6H4OH) (6-X, X = H, CH3, OCH3, Cl, Br): An Approach to Electrocatalytic CH Bond Activation."  Polyhedron 2004, 22, 2841-2856.
  •                 K.P. Knutsen, J.C. Johnson, A.E. Miller, P.B. Petersen and R.J. Saykally, “High spectral resolution multiplex CARS spectroscopy using chirped pulses,” Chem. Phys. Lett. 387, 436-441 (2004)
  •                 B.L. Weeks, A. Noy, A.E. Miller, J.E. Klare, B.W. Woods, and J.J. De Yoreo, "Dip-Pen Nanolithography using MHA and Optical Inks," Dekker Encyclopedia of Nanoscience and Nanotechnology, Marcel Dekker, 923-931 (2003)
  •                 B.L. Weeks, J. Camarero, A. Noy, A.E. Miller, L. Stanker and J.J. De Yoreo. “A Microcantilever-Based Pathogen Detector” Scanning 25, 297-299 (2003) A. Noy, A.E. Miller, J.E. Klare, B.L. Weeks, B.W. Woods, and J.J. De Yoreo "Fabrication and imaging of luminescent nanostructures and polymer nanowires using dip-pen nanolithography" Nano Letters 2(2)  09-112 (2002)
  •                 B.L. Weeks, A. Noy, A.E. Miller, and J.J. De Yoreo. The effect of dissolution kinetics on feature size in dip-pen nanolithography. Phys. Rev. Lett., 88, 255505 (2002). Also in Virtual Journal of Nanoscale Science & Technology, June 24, 2002.

Honors, Awards, and Fellowships

  • National Research Council Postdoctoral Fellowship
  • Lawrence Livermore Nat. Lab Student-Employee Graduate Research Fellowship

Professional Presentations

  • A. E. Miller “Prion Aptamers, Free and Bound States” Biophysical Society Meeting, San Francisco, CA (February 2010) (poster)
  • A. E. Miller  “Aptamer Dynamics” Division of Physical Chemistry 238nd ACS National Meeting – Washington DC (August 2009) (poster)
  • A. E. Miller “ Aptamer Dynamics” Sigma Xi Postdoctoral Posters, Gaithersburg, MD February 2009 (poster)
  • A. E. Miller “Single Molecule Analysis of PrP Aggregation” Single Molecule Approaches to Biology, Gordon Conference, New London, NH, August 2008 (poster)
  • A. E. Miller “Applications of Optical Spectroscopy to the Study of Protein Aggregation” Physics Laboratory, NIST, Gaithersburg, MD October 29, 2007
  • A. E. Miller “Applications of Optical Spectroscopy to the Study of Protein Aggregation” Georgia Tech, Atlanta, GA October 1, 2007
  • A.E. Miller “Investigating beta amyloid 1-16 at the air-water interface and beyond”  T. Head Gordon Group, UC-Berkeley, Berkeley, CA September 12, 2007
  • A.E. Miller* P.B. Petersen, C. W. Hollars, and R. J. Saykally “ Investigating beta amyloid 1-16 at the air-water interface” Division of Physical Chemistry 234nd ACS National Meeting – Boston, MA (August 19-23, 2007)  (poster)
  • A.E. Miller “Application of Fluorescence Correlation Spectroscopy to Protein aggregation” Biophysics Seminar, Department of Physics, University of Illinois, Urban-Champaign, Urbana, IL February 16, 2007
  • A.E. Miller*, T. Laurence, R.J. Saykally, and C.W. Hollars “Locating Proteins in Solution via Fluorescence Cross Correlation Spectroscopy” Center for Analytical Biotechnology, Berkeley, CA December 8, 2006 (presentation)     

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