Jason D'Antonio

Professorial Lecturer
Department of Biology

• Jason's research interests include hormone signaling in prostate cancer, specifically the adaptive role of the androgen receptor (AR) in disease progression to advanced, metastatic, hormone-refractory disease. In normal prostate the AR functions as a tumor suppressor, inducing growth inhibition of the glandular, luminal epithelial cells. During prostate carcinogenesis, there is a conversion in AR signaling from that of growth inhibition to growth stimulation, a process that is often associated with AR mutation, duplication, and over-expression. Understanding the cellular and molecular mechanisms involved in AR signaling during the progression of prostate cancer is essential for developing more effective therapeutic approaches to treating this devastating disease.