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John Bracht

Assistant Professor Department of Biology

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CAS - Biology
Hurst - 111
Office: Hurst 111 Lab: Hurst B12
Contact Info
(202) 885-2189

Send email to John Bracht

For the Media
To request an interview for a news story, call AU Communications at 202-885-5950 or submit a request.


Scholarly, Creative & Professional Activities

Selected Publications

Chen X1, Bracht JR1, Goldman A, Swart E, Dolzhenko E, Swart E, Clay D, Perlman DH, Doak TG, Stuart A, Amemiya C, Landweber LF. The architecture of a scrambled genome reveals massive levels of genomic rearrangement during development. Cell, in press (Aug. 28, 2014). (1 Equal contribution.)

Bracht JR. Beyond transcriptional silencing: Is cytosine methylation a widely conserved eukaryotic DNA elimination mechanism? BioEssays. April 2014 36(4):346-52.

Bracht JR, Fang W, Goldman AD, Dolzhenko E, Stein EM, Landweber LF. Genomes on the Edge: Programmed Genome Instability in Ciliates. Cell. 2013 Jan 31;152(3):406-416.

Swart E, Bracht JR, Magrini V, Minx P,Chen X, Zhou Y, Khurana J, Goldman AD, Nowacki M, Schotanus K, et al. The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome with over 16,000 Tiny Chromosomes. PLoS Biology. 2013 Jan 29;11(1).

Fang W, Wang X, Bracht JR, Nowacki M, Landweber LF. Piwi-Interacting RNAs Protect DNA Against Loss During Oxytricha Genome Rearrangement. Cell. 2012 Dec 7;151(6):1243-1255.

Bracht JR*, Perlman DH, Landweber LF*. Cytosine methylation and hydroxymethylation mark DNA for elimination in Oxytricha trifallax. Genome Biology. 2012 Oct 17;13(10):R99.  *corresponding.

Honors, Awards, and Fellowships

K22 Transition Career Development Award (National Cancer Institute): Model systems for the investigation of DNA methylation and drug repurposing (2014-2017)

F32 NRSA Postoctoral Fellowship: Epigenetic regulation of programmed genome instability in O. trifallax (2012-2014)

AU Expert

Area of Expertise:

cell biology, genomics, computational genomics

Additional Information:

As an assistant professor in AU's Dept. of Biology, Bracht researches how genome architecture is established and maintained in healthy cells and how it goes awry in disease. He uses a unicellular eukaryote, the ciliate Oxytricha trifallax, as a model system for the role of epigenetics — information on the DNA molecule but outside the DNA sequence — in controlling genome architecture.

Media Relations
To request an interview please call AU Media Relations at 202-885-5950 or submit an interview request form.