Profile

Visiting Scientist,

Division of Inflammation Biology,

La Jolla Institute for Allergy and Immunology,

9420 Athena Circle,

La Jolla, CA 92037,

mpospieszalska@liai.org

Maria Pospieszalska

Professorial Lecturer
Department of Mathematics and Statistics

  • Prior to joining AU, Dr. Maria K. Pospieszalska held research scientist positions at the Department of Materials Science and Engineering, University of Virginia, the Department of Biomedical Engineering and Cardiovascular Research Center, University of Virginia, and the Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA. She has taught numerous courses (differential equations, probability, actuarial statistics, biostatistics, and many more) for three major universities.

    Dr. Pospieszalska's research interest is in modeling of physical and biophysical processes. Her earlier publications are in the field of atmospheric physics and include modeling the neutral cloud and heavy ion inner torus of Saturn, the erosion of rings and density of the Cassini division of Saturn, atmospheric sputtering on Mars, and plasma sputtering of Io's atmosphere. Her recent publications are in the field of biophysics and include modeling of processes in blood vessels such as cell rolling in shear flow, formation of cell tethers, and adhesion molecules' interaction in inflammation including atherosclerosis.

  • Degrees

    Ph.D., Mathematics, Warsaw University of Technology, Poland;
    M.S., Mathematics, Jagiellonian University, Cracow, Poland

  • OFFICE

  • CAS - Math & Statistics
  • Gray - 102

  • CONTACT INFO

  • (202) 885-6472
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  • FOR THE MEDIA

  • To request an interview for a
    news story, call AU Communications
    at 202-885-5950 or submit a request.

Teaching

  • Spring 2013

    • STAT-202 Basic Statistics: Basic Statistics - SOC/POL
    • Description

Scholarly, Creative & Professional Activities

Selected Publications

Peer-Reviewed Publications:

P. Sundd, M. K. Pospieszalska and K. Ley. Neutrophil Rolling at High Shear: Flattening, Cath Bonds, Tethers and Slings. Molecular Immunology, in press.

P. Sundd, E. Gutierrez, E. Koltsova, Y. Kuwano, S. Fukuda, M. K. Pospieszalska, A. Groisman and K. Ley. ‘Slings’ enable neutrophil rolling at high shear.  Nature 488: 399-403 (2012).

B. Kaltenbacher, I. Lasiecka and M. K. Pospieszalska. Well-Posedness and Exponential Decay of the Energy in the Nonlinear Jordan-Moore-Gibson-Thompson Equation Arising in High Intensity Ultrasound. Mathematical Models and Methods in Applied Sciences 22: 1250035 (2012).

P. Sundd, E. Gutierrez, M. K. Pospieszalska, E. Koltsova, Y. Kuwano, S. Fukuda, A. Groisman and K. Ley. Neutrophil Sling: a New Cell-Autonomous Adhesive Structure Enabling Rolling at High Shear Stress. Biophys. J. 102:194-195 (2012).

M. K. Pospieszalska, I. Lasiecka and K. Ley. Cell Protrusions and Tethers. Biophys. J. 100:1697-1707 (2011).

 P. Sundd, M. K. Pospieszalska, L. S.-L. Cheung, K. Konstantopoulos and K. Ley. Biomechanics of Leukocyte Rolling at High Shear Stress. Biorheology 48:1-35 (2011).

P. Sundd, E. Gutierrez, M. K. Pospieszalska, H. Zhang, A. Groisman and K. Ley. Quantitative Dynamic Footprinting Microscopy Reveals Mechanisms of Neutrophils Rolling. Nature Methods 7:821-824 (2010).

P. Sundd, E. Gutierrez, M. Pospieszalska, A. Groisman, K. Ley. Stressed and Compressed Molecular Bonds Revealed in Footprints of Rolling Neutrophils using Total Internal Reflection Fluorescence Microscopy. Biophys. J. 98: 595 (2010).

M. K. Pospieszalska and K. Ley. Dynamics of Microvillus Extension and Tether Formation in Rolling Leukocytes. Cell. Mol. Bioeng. 2:207-212 (2009)..

M. K. Pospieszalska, A. Zarbock, J. E. Pickard and K. Ley. Event Tracking Model of Adhesion Identifies Load-Bearing Bonds in Rolling Leukocytes. Microcirculation 16:115-130 (2009).

M. K. Pospieszalska and R. E. Johnson. Monte Carlo Calculations of Plasma Ion-induced Sputtering of an Atmosphere: SO2 Ejected From Io. J. Geophys. Res.101:7565-7573 (1996).

D. Breuer, H. Zhou, D. A. Yuen, T. Spohn, E. Tajika, S. Sasaki, C. R. Kerton, F. P. Fanale, J. R. Salvail, M. K. Pospieszalska, R. E. Johnson, D. W. Clarke, J. P. Ferris, L.R. LeClair, J. M. Derbyshire, J. W. McConkey, T. Majeed, J. C. McConnell, A. M. Krymskii, T. K. Breus, J. G. Luhmann. The stability of climate on Venus. J. Geophys. Res. 101: 7521-7529 (1996).

M. K. Pospieszalska and R. E. Johnson. Plasma Heating of Io's Atmosphere. Geophysical Research Letters 19:949-952 (1992).

R. E. Johnson, M. K. Pospieszalska and W. L. Brown. Linear-to-Quadratic Transition in Electronically Stimulated Sputtering of Solid N2 and O2. Physical Review 44:7263-7272 (1991).

M. K. Pospieszalska and R. E. Johnson. Micrometeoritic Erosion of the Main Rings as a Source of Plasma in the Inner Saturnian Plasma Torus. Icarus 93:45-52 (1991).

M. K. Pospieszalska and R. E. Johnson. Magnetospheric Ion Bombardment Profiles of Satellites:  Europa and Dione. Icarus 78:1-13 (1989).

R. E. Johnson, M. K. Pospieszalska, E. C. Sittler, A. F. Cheng, L. J. Lanzerotti and E. M. Sieveka. The Neutral Cloud and Heavy Ion Inner Torus at Saturn. Icarus 77:311-329 (1989).

M. K. Pospieszalska. Relations Between Local Extrema of a Certain Class of Functionals. Houston Journal of Mathematics 14:265 279 (1988).

   

 BOOK CHAPTERS:

M. K. Pospieszalska and K. Ley. Modeling Leukocyte Rolling. In Leukocyte Adhesion edited by K. Ley. Current Topics in Membranes 64:221-273 (2009).

K. Ley, X Mestas, M. K. Pospieszalska and A. Zarbock. Intravital Microscopic Investigation of Leukocyte Interactions with the Blood Vessel Wall. In Angiogenesis: In Vivo Systems edited by D. A. Cheresh. Methods in Enzymology 445:255-279 (2008).

 

SELECTED PROFESSIONAL PRESENTATIONS:

M. K. Pospieszalska. Comprehensive Theory and Modeling of Cell Tethering. Presented at the La Jolla Institute for Allergy and Immunology, 2009.

M. K. Pospieszalska. Sensitivity of cell rolling to microvillus density. Slow and fast cells rolling at constant shear rates.  Presented at the La Jolla Institute for Allergy and Immunology, 2009.

M. K. Pospieszalska. Physics of Cell Tethering. Presented at the University of Virginia. 2009.

M. K. Pospieszalska. Event-Tracking Model of Adhesion (ETMA) Identifies Load-Bearing Bonds in Leukocyte Rolling at Low Shear. Presented at the La Jolla Institute for Allergy and Immunology, 2007.

M. K. Pospieszalska. Modeling Microvillus Deformation. Study in Progress. Presented at the University of Virginia, 2006.

M. K. Pospieszalska. Study of Leukocytes Rolling on P-selectin Based on Event-Tracking Model of Adhesion. Part II. Presented at the University of Virginia, 2004.

M. K. Pospieszalska. Study of Leukocytes Rolling on P-selectin Based on Event-Tracking Model of Adhesion. Part I. Presented at the University of Virginia, 2004.

 

Announcements

       BIOSTATISTICS COURSES

       at AMERICAN UNIVERSITY

Sprnig 2013:

STAT 320 - Biostatistics

Fall 2013:

STAT 517 - Topics: Advanced Biostatistics