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Psychopharmacology | Lab Members

Katie Serafine

ks3234a@student.american.edu

Curriculum Vitae

 

I'm a fifth year PhD student here at AU. My research in the Psychopharmacology Laboratory has focused on the aversive effects of cocaine. Specifically, I have used the cross-drug preexposure procedure to assess the common aversion-inducing effects between compounds that selectively inhibit norepinephrine, serotonin and dopamine transporters and those of cocaine, a non-selective monoamine transport inhibitor. In the future, I plan to continue to examine the mechanisms involved in cocaine-induced conditioned taste aversions via the administration of selective antagonists for dopamine and serotonin receptors, as well as investigating transgenic knockout mice in the CTA preparation with cocaine. I am interested in continuing research examining the aversive effects of cocaine as well as research assessing how drug history affects the aversive and rewarding properties of other drugs.

PUBLICATIONS

Serafine KM, Riley AL (in preparation). Cocaine-induced conditioned taste aversions: Investigations of neurochemical mediation, In Hall, FS. ed. Serotonin: Biosynthesis, Regulation and Health Implications, Hauppauge, NY: NOVA Science Publishers, Inc.

Serafine KM, Briscione, MA, Rice, KC, Riley AL (in preparation). The effects of cross-drug preexposure on GBR 12909- and cocaine-induced conditioned taste aversions.

Serafine KM, Briscione, MA, Riley AL (2011). The effects of dopamine antagonism on cocaine-induced conditioned taste aversions. Physiology and Behavior, DOI: http://www.sciencedirect.com/science/article/pii/S0031938411005695

Serafine KM. Review: Preexposure to the Unconditioned Stimulus in Nausea-Based Aversion Learning by Geoffrey Hall. Online Dec 2010. [PDF]

Serafine KM, Riley AL (2010). Preexposure to cocaine attenuates aversions induced by both cocaine and fluoxetine: Implications for the basis of cocaine-induced conditioned taste aversions. Pharmacology, Biochemistry & Behavior; 95: 230-234.

Serafine KM, Riley AL (2009). Possible role of norepinephrine in cocaine-induced conditioned taste aversions. Pharmacology, Biochemistry & Behavior; 92: 111-116.

Roma PG, Rinker JA, Serafine KM, Chen SA, Barr CS, Cheng K, Rice KC, Riley AL (2008). Genetic and early environmental contributions to alcohol’s aversive and physiological effects. Pharmacology, Biochemistry & Behavior; 91: 134-139.

CONFERENCE PRESENTATIONS

Poster Presentations

Serafine, K.M., Rice, K.C., and Riley, A.L. (2011, August). The assessment of the neurochemical mediation of cocaine-induced conditioned taste aversions. Poster presented at the NIDA/NIAAA/APA (Divisions 28 & 50) Early Career Investigators Poster Session in conjunction with the American Psychological Association's annual meeting, Washington, DC.

Serafine, K.M., Briscione, M.A., Rice, Hall, F.S., Uhl, G.R., and Riley, A.L. (2011, August). The role of monoamines in cocaine-induced conditioned taste aversions. Poster presented at the NIH Summer Research Program Poster Day, Bethesda, MD.

Serafine, K.M., Rice, K.C., and Riley, A.L. (2011, June). The effects of cross- drug preexposure on cocaine- and vanoxerine-induced conditioned taste aversions. Poster accepted for presentation at the annual meeting of the College on Problems of Drug Dependence, Hollywood, FL.

Serafine, K.M., Rice, K.C., and Riley, A.L. (2011, April). Effects of cross-drug preexposure on cocaine- and vanoxerine-induced conditioned taste aversions. Poster accepted for presentation at the annual meeting of the American Society for Pharmacology and Experimental Therapeutics, Washington, DC.

Serafine, K.M. (2011, March) The assessment of the neurochemical mediation of cocaine-induced conditioned taste aversions. Oral communication presented at the annual meeting of Behavior, Biology and Chemistry: Translational Research in Addiction (BBC), San Antonio, TX.

Serafine, K.M., and Riley, A.L. (2010, April). The effects of cross-drug preexposure on cocaine- and fluoxetine-induced conditioned taste aversions. Poster presented at the annual meeting of the American Society for Pharmacology and Experimental Therapeutics, Anaheim, CA.

Serafine, K.M., and Riley, A.L. (2009, June) The effects of cross-drug preexposure on cocaine- and desipramine-induced conditioned taste aversions. Poster presented at the annual meeting of the College on Problems of Drug Dependence, Reno, NV.

Serafine, K.M., and Riley, A.L. (2009, April). The effects of antidepressant drug history on cocaine-induced conditioned taste aversions. Poster presented at the 19th Annual Robin Rafferty Mathais College of Arts and Sciences Student Research Conference, American University, Washington DC.

Serafine, K.M., Rinker, J.A., Roma, P.G., Cheng, K., Rice, K.C., and Riley, A.L. (2008, June). Effects of nor-BNI on ethanol-induced conditioned taste aversions in both in- and cross-fostered Lewis and Fischer female rats. Poster presented at the annual meeting of the College on Problems of Drug Dependence, San Juan, Puerto Rico.

Rinker, J.A., Serafine, K.M., Roma, P.G., Cheng, K., Rice, K.C., and Riley, A.L. (2008, June). Effects of nor-BNI on self-administration of ethanol in cross- and in-fostered Lewis and Fischer female rats. Poster presented at the annual meeting of the College on Problems of Drug Dependence, San Juan, Puerto Rico.

Serafine, K.M., and Bandy, C.L. (2005, May) The effects of lifestyle and priming on conformity behavior and the effect of conformity on cognitive dissonance among Norwich University students. Presented at the Norwich University/Castleton State College Psychological Conference, Castleton State College, Castleton, VT.

Invited Talks

Serafine, K.M. (2011, September). Monoaminergic mediation of cocaine-induced conditioned taste aversions. Presented at the Department of Pharmacology at the University of Texas Health Science Center, San Antonio, TX.

Serafine, K. M. (2011, February) The assessment of the neurochemical mediation of cocaine-induced conditioned taste aversions. Presented at the Molecular Neurobiology Branch of the National Institute of Health Intramural Research Program of the National Institute on Drug Abuse, Baltimore, MD.

Katie Serafine