Department of Biology
- Jason's research interests include hormone signaling in prostate cancer, specifically the adaptive role of the androgen receptor (AR) in disease progression to advanced, metastatic, hormone-refractory disease. In normal prostate the AR functions as a tumor suppressor, inducing growth inhibition of the glandular, luminal epithelial cells. During prostate carcinogenesis, there is a conversion in AR signaling from that of growth inhibition to growth stimulation, a process that is often associated with AR mutation, duplication, and over-expression. Understanding the cellular and molecular mechanisms involved in AR signaling during the progression of prostate cancer is essential for developing more effective therapeutic approaches to treating this devastating disease.
- CAS - Biology
- Hurst - 112B
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Scholarly, Creative & Professional Activities
- D'Antonio JM, et.al., (2010) Loss of Androgen Receptor-Dependent Growth Suppression by Prostate Cancer Cells Can Occur Independently from Acquiring Oncogenic Addiction to Androgen Receptor Signaling. PLoS ONE 5(7): e11475.