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Biology Faculty Research Interests

American University's Department of Biology offers expertise in a wide range of disciplines including cell and developmental biology, neuroscience, ecology, evolution, genetics, and marine biology. Our faculty are equally committed to excellence in both research and teaching.

Please see below for Recent Faculty Publications.
 

Oxytricha triffallax

John Bracht

For an organism to survive, the genome, the complete set of DNA in a cell, must be stably maintained and correctly regulated. Given the central importance of the genome, it is surprising that some organisms simply eliminate significant portions of it from some or all cells. Genome changes are also linked to cancer, a fundamentally genomic disease. My lab works on interesting questions surrounding genome dynamics: how does the organism maintain — and sometimes purposefully alter — its genome architecture, and how can it go awry in disease? Genomic methods used in this work include next-generation sequencing of DNA and RNA, cell culture, and computational methods. A particular focus of my laboratory is the role of epigenetics: a genetic code-on-a-code-in controlling genome structure and function.

The Bracht lab investigates the process of genome rearrangement in the ciliate Oxytricha trifallax. During genome rearrangement, this remarkable organism pieces together its genome from pieces much as one might assemble a jigsaw puzzle.

 

Graph: cave expression vs surface expression

David Carlini

I am interested in molecular evolution and empirical population genetics. Current projects in my lab include: 1) transcriptome profiling of cave and surface populations of freshwater crustaceans, with an aim toward identifying and characterizing patterns of variation in differentially regulated genes, 2) experimental alteration of synonymous codons in bacterial antibiotic resistance genes, and 3) characterization of oncogenic mutations in squamous cell carcinomas of Tpl2-knockout mice.

 

 

Zebrafish neurons

Victoria Connaughton

Dr. Connaughton's research interests encompass the disciplines of developmental biology (nervous system development) and neurobiology. Specifically, she is interested in examining the relation between visually-guided behaviors in larval teleosts and maturation of retinal neurons, circuits, and receptor mechanisms. She is also interested in examining how the development of neural connections could be altered due to mutations or drugs. She has performed experiments that address behavioral/ecological questions, as well as those that employ cell biology techniques to examine retinal circuitry in both developing and adult retinal tissue.

 

Microscopic image of mouse cells

Kathleen DeCicco-Skinner

Chair
Broadly speaking our laboratory studies molecular changes that contribute to cancer development as well as the role of the tumor microenvironment in the initiation and progression of cancer. We have two active areas of research in our laboratory. (1) The first area of research investigates one specific signaling pathway defect and how it predisposes to squamous cell carcinoma, a form of skin cancer. The tumor progression locus 2 (Tpl2) gene is involved in a variety of cellular functions including inflammatory processes and immune function. We have recently identified a novel tumor suppressor role of Tpl2 in chemically-induced skin cancer. Tpl2-/-mice have higher incidences of cutaneous papillomas than wildtype mice and these papillomas convert to cutaneous squamous cell carcinoma more readily than in wildtype mice. Currently, we are working to understand the stromal-epithelial interactions that drive skin cancer development and progression in Tpl2-/- mice. (2) Multiple myeloma is the second most common blood cancer in the United States. Epidemiological studies have identified obesity as a risk factor for multiple myeloma. Obesity increases both the risk of developing multiple myeloma and decreases overall patient survival. However, the molecular underpinnings by which adipocytes (fat cells) contribute to multiple myeloma growth and progression is relatively unknown. Our laboratory is working to understand the hormonal, lipid, and signaling factor dysregulation in obese adipocytes that contribute to MM growth and progression.

 

A closeup picture of an undeveloped shrimp

Daniel Fong

My research is focused on the evolution, ecology, and conservation of subterranean organisms, especially groundwater-dwelling amphipod and isopod crustaceans. The amphipod Gammarus minus is an especially useful model organism because subterranean and surface populations with different morphologies exist, allowing for comparative studies. Current ongoing projects include: 

  1. Long-term monitoring of population dynamics of the amphipod Stygobromus tenuis potamacus and the isopod Caecidotea kenki from seepage springs using mark-recapture methods
  2. Interactions of size-selective predation by fish and sexual selection on the body size of the amphipod Gammarus minus, and the cascading effect of body size variation among populations on macroinvertebrate community structure in karst springs
  3. Molecular phylogeography and genetic adaptations to the subterranean environment, in collaboration with David Carlini
  4. Mechanisms of evolutionary loss of body pigmentation in subterranean organisms.

 

Graphical representation of a biofilm

Jeffrey Kaplan

Biofilms are densely-packed communities of bacteria, encased in a self-synthesized polymeric matrix, growing attached to a tissue or surface. Biofilm is the predominant mode of growth for bacteria in most natural, industrial and clinical environments. Biofilm formation causes major problems ranging from industrial corrosion and biofouling to chronic or nosocomial infections. Kaplan's lab is studying the detachment and dispersal of cells from bacterial biofilms. The emphasis of his research is the use of biofilm matrix-degrading enzymes as potential antibiofilm therapies for the treatment and prevention of various human, animal and plant infections. Kaplan's lab has received funding from the National Institute of Allergy and Infectious Diseases and from private industry.

 

Research figure

Naden Krogan

Stem cells are crucial for the growth and development of multicellular organisms. We are interested in how stem cell activity is regulated by gene expression. Our work focuses on transcription factors that dictate the proper spatial and temporal expression of genes in stem cell microenvironments. Without this regulation, stem cell activity is dysfunctional and organisms develop abnormally. Our investigations utilize the plant model Arabidopsis thaliana since stem cells are essential for the generation of new organs throughout its lifecycle. We primarily study reproductive development, and employ molecular, genetic and genomic approaches to interrogate the role of stem cell populations during this agronomically important stage. With this work, we aim to better understand how transcriptional regulation maintains stem cell integrity and to offer strategies for improving crop productivity.

 

inter-trial coherence: reward value

Mark Laubach

Mark Laubach is a neurobiologist interested in the neural basis of goal-directed behavior. His laboratory is examining the roles of the prefrontal cortex and basal ganglia in executive control and decision making. Core methods include multi-electrode recordings, optogenetics, multivariate statistics, and computational models of neural circuits.

Zebrafinches

Colin Saldanha

Hormones are profound modulators of brain structure and function; with influences that span the lifetime of an organism. The muti-faceted and pluripotent neural effects of steroids require that a specific hormone be delivered to the right target at precisely the right time. Members of my laboratory and I are curious as to how this process occurs. We have discovered that estrogen is synthesized in synaptic boutons and in astroglia (a type of non-neuronal cell in the brain). This compartment- and cell-specific hormone provision may be responsible for the effects of estrogen on learning, memory, neural degeneration and perhaps neuroprotection and repair.

 

Hormone model

Catherine Schaeff

Dr. Schaeff's training is in behavior and evolutionary biology. Her research interests include social behavior, conservation biology, molecular ecology and most recently, human sexual identity - examining the biological foundations of human gender and sexual orientation.

There is data that suggests that individuals with gender dysphoria (i.e., transgendered individuals) who receive sex hormones as part of their transition may experience a shift in their sexual orientation and/or gender identities. To social scientists, gender is primarily a social construct, connected to an individual's sex or sexual orientation mostly through socially constructed links. To natural scientists, it is a flexible behavioral aspect that evolved because it facilitated obtaining high quality mates and maximizing one's reproductive success. Investigating whether, and if so how, sex hormones affect sexual identity (gender and sexual orientation) is important both for enhancing our understanding of sexual identity and because it will provide information and insights for transitioning individuals and the practitioners who support them. This work incorporates biological, psychological, and sociological theories and methodologies.

 

Decapod crustaceans

Christopher Tudge

Dr. Tudge is primarily a reproductive biologist with particular interests in the reproductive biology of invertebrates. His research focuses on the reproductive cells and associated structures, evolutionary mechanisms, and reproductive behaviors of marine decapod crustaceans. He also has experience dealing with other invertebrate and vertebrate groups and his knowledge of reproduction in crustaceans can be directly applied to other taxa. He uses this interest in crustacean reproduction to investigate the evolutionary history (phylogeny) of particular crabs in marine and freshwater environments. Tudge also has an interest in bird biology, ecology and systematics.

 

Recent Publications

  • Bullwinkle, EM, Parker, MD, Bonan, NF, Falkenberg, LG, Davison, SP, DeCicco-Skinner, KL. (2016) Adipocytes contribute to the growth and progression of multiple myeloma: Unraveling obesity related differences in adipocyte signaling. Cancer Letters. 380(1), 114-121.

  • Davis, CM, DeCicco-Skinner, KL, Hienz, RD. (2015) Deficits in Sustained Attention and Changes in Dopaminergic Protein Levels Following Exposure to Proton Radiation are related to Basal Dopaminergic Function. PLoS One. 10(12):e0144556.

  • Wetzell, BB†, Muller, MM†, Flax, SM, King, HE, DeCicco-Skinner, KL, Riley, AL. (2015) Effect of Preexposure on Methylphenidate-Induced Taste Avoidance and Related BDNF/TrkB Activity in the Rat. Psychopharmacology. 232, 2837-2847.

  • Davis CM, DeCicco-Skinner KL, Roma PG, and Hienz RD. (2014) Changes in Neurobehavioral Performance and Dopaminergic Function Associated with Exposure to Space Radiation. Radiation Research. 181, 258-271.

  • Wetzell, BB†, Muller, MM†, Cobuzzi, JL†, Hurwitz, ZE†, DeCicco-Skinner, KL, Riley, AL. (2014). Effect of age on methylphenidate-induced conditioned taste avoidance and related BDNF/TrkB signaling in the insular cortex of the rat. Psychopharmacology. 231(8):1493-501.

  • DeCicco-Skinner KL, Henry GH†, Cataisson C, Tabib T†, Gwilliam JC†, Watson N†, Bullwinkle, EM†, Falkenberg, L†, O'Neill R†, Moran, A, Wiest JS. (2014) Endothelial cell tube formation assay for the study of in vitro angiogenesis. J. Vis. Exp. (91), e51312.
  • Walters-Conte, K. B., Johnson, D. L., Johnson, W. E., O'Brien, S. J., & Pecon-Slattery, J. (2014). The dynamic proliferation of CanSINEs mirrors the complex evolution of Feliforms. BMC Evolutionary Biology, 14, 137. http://doi.org/10.1186/1471-2148-14-137

  • Bailey, DJ & Saldanha, CJ. (2018). Estrogenic regulation of spatial memory in songbirds. In: Estrogens and Memory: Basic Research and Clinical Implications. Frick KM (Ed). Oxford University Press.

  • Pedersen, AL. & Saldanha CJ. (2017). Reciprocal interactions between prostaglandin E2- and estradiol-dependent signaling pathways in the injured zebra finch brain. J. Neuroinflammation. 14(1): 262

  • Pedersen, AL, Brownrout, JL, & Saldanha CJ. (2017). Neuroinflammation and neurosteroidogenesis: Reciprocal modulation during injury to the adult zebra finch brain. Physiol & Behav S0031-9384(17)30352-9. Epub ahead of print.

  • Pedersen, AL, Gould CL & Saldanha CJ. (2017). Activation of the peripheral immune system regulates neuronal aromatase in the adult zebra finch brain. Scientific Reports. 7(1): 10191.

  • Pedersen, AL, Brownrout, JL, & Saldanha CJ. (2017). Central administration of indomethacin mitigates the injury-induced upregulation of aromatase expression and estradiol content in the zebra finch brain. Endocrinology. 158(8): 2585-92.

  • Bailey DJ, Makeyeva, YV, Paitel, ER, Pedersen, AL, Hon, AT, Gunderson, JA & Saldanha, CJ. (2017). Hippocampal aromatization modulates spatial memory and characteristics of the synaptic membrane in the male zebra finch. Endocrinology. 158(4): 852-859.

  • Pedersen AL & Saldanha CJ. (2017). Steroids and Plasticity. In: Oxford Encyclopedia of Neuroendocrine and Autonomic Systems. Nelson RJ (Ed). Oxford University Press.

  • Pedersen, AL, Nelson, LH & Saldanha, CJ. (2016). Centrally Synthesized Estradiol is a Potent Anti-Inflammatory in the Injured Zebra Finch Brain. Endocrinology 157(5): 2041-51.

  • Mehos, CM, Nelson, LH & Saldanha CJ. (2016). A quantification of injury-induced aromatase expression and estrogenic milieu in the zebra finch (Taeniopygia guttata). J. Neuroendocrinol. 28(2).

  • Bailey DJ & Saldanha CJ. (2015).The importance of neural aromatization in the acquisition, recall, and integration of song and spatial memories in passerines. Horm Behav. 27(15): 116-124.

  • Calisi RM & Saldanha CJ. (2015). Neurohormones, Brain, and Behavior: A Comparative Approach to Understanding Rapid Neuroendocrine Action. Integr Comp Biol. 55(2):264-7.

  • Saldanha, CJ, Mehos, CJ, Pedersen, AL & Wiggins, WA. (2015). Astrocytic aromatization and injury. In: Estrogens and Traumatic Brain Injury. Ducan, KA (Ed). Elsevier.

  • Gould, CJ, J Wiegand, and VP Connaughton. 2017. Acute developmental exposure to 4-hydroxyandrostenedione has a long-term effect on visually-guided behaviors. Neurotoxicology and Teratology. 64: 45-49.

  • Clayman, CL, E. Malloy, D. Kearns, and VP Connaughton. 2017. Differential Behavioral Effects of Ethanol Pre-Exposure in Male and Female Zebrafish (Danio rerio). Behavioral Brain Research. 335: 174-184.

  • Bentley, M., and Connaughton, V.P. 2017. A simple way for students to visualize cellular respiration: Adapting the board game MousetrapTM to model complexity. CourseSource. DOI: 10.24918/cs.2017.8

  • Carvan MJ III, Kalluvila TA, Klingler RH, Larson JK, Pickens M, Mora-Zamorano FX, Connaughton VP, Sadler-Riggleman I, Beck D, Skinner MK. 2017. Mercury-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in zebrafish. PloS One. 12:e0116155. DOI: 10.731/journal.pone.0176155

  • LeFauve, M** and VP Connaughton. 2017. Developmental exposure to heavy metals alters visually-guided behaviors in zebrafish. Current Zoology. 63(2): 221-227. DOI: 10.1093/cz/zox017

  • Torvund, MM, TS Ma, VP Connaughton, F Ono, and RF Nelson. 2016. Cone signals in the monostratified and bistratified amacrine cells of adult zebrafish retina. Journal of Comparative Neurology. 525: 1532-1557. DOI: 10.1002/cne.24107

  • Tarboush, R**, G Chapman, VP Connaughton. 2016. Abnormal rearing light levels delay retinal development and alter photoreceptor synaptic ultrastructure in larval zebrafish. European Journal of Anatomy. 20: 159-169.
  • Connaughton, VP, C Baker**, L Fonde**, E Gerardi**, C Slack**. 2016. Alternate immersion in an external glucose solution differentially affects blood sugar values in older vs. younger zebrafish adults. Zebrafish. 13: 87-94. DOI: 10.1089/zeb.2015.1155

  • Connaughton, VP, BB Wetzell, LS Arneson, V Delucia, and A Riley. 2015. Elevated dopamine concentration in light-adapted zebrafish retinas is correlated with increased dopamine synthesis and metabolism. Journal of Neurochemistry. 135: 101-108. DOI: 0.1111/jnc.13264

  • Reider, M** and VP Connaughton. 2015. Developmental exposure to methimazole increases anxiety behavior in zebrafish. Behavioral Neuroscience. 129: 634-642. DOI: 10.1037/bne0000087

  • Pelli, M** and VP Connaughton. 2015. Chronic exposure to environmentally-relevant concentrations of fluoxetine (Prozac) decreases survival, increases abnormal behaviors, and delays predator escape responses in guppies (Poecilia reticulata). Chemosphere. 139: 202-209. DOI: 10.1016/j.chemosphere.2015.06.033

  • Reider, M**, VP Connaughton. 2014. Effects of thyroid inhibition and rearing temperature on zebrafish development. Birth Defects Research part B: Developmental and Reproductive Toxicology. 101: 347-354. DOI: 10.1002/bdrb.21118

  • Tarboush, R**, I N Flamarique, G Chapman, VP Connaughton. 2014. Variability in mitochondria of zebrafish photoreceptor ellipsoids. Visual Neuroscience. 31: 11-23. DOI: 10.1017/S095252381300059X

  • Amarante, L. M., Caetano, M. S., Laubach, M. (2017). Medial Frontal Theta Is Entrained to Rewarded Actions. Journal of Neuroscience, 37(44), 10757-10769.

  • Narayanan, N. S., Laubach, M. (2017). Inhibitory Control: Mapping Medial Frontal Cortex. Current Biology, 27(4), 148-150.

  • Parent MA, Amarante LM, Swanson K, Laubach M. (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Front Behav Neurosci. 2015 Oct 26;9:284.

  • Parent MA, Amarante LM, Liu B, Weikum D, Laubach M. (2015) The medial prefrontal cortex is crucial for the maintenance of persistent licking and the expression of incentive contrast. Front Integr Neurosci. 2015 Mar 27;9:23.

  • Laubach M, Caetano MS, Narayanan NS. Mistakes were made: neural mechanisms for the adaptive control of action initiation by the medial prefrontal cortex. J Physiol Paris. 2015 Feb-Jun;109(1-3):104-17.

  • Carlini, D.B.*, S. Satish, and D.W. Fong. 2013. Parallel reduction in expression, but no loss of functional constraint, in two opsin paralogs within cave populations of Gammarus minus (Crustacea: Amphipoda). BMC Evolutionary Biology 13:89. https://doi.org/10.1186/1471-2148-13-89

  • MacAvoy, S.E., A. Braciszewski, E. Tengi, and D.W. Fong*. 2016. Trophic plasticity among spring versus cave populations of Gammarus minus: examining functional niches using stable isotopes and C/N ratios. Ecological Research 31:589-595. https://doi.org/10.1007/s11284-016-1359-6

  • Niemiller, M.L.*, M.L. Porter, J. Keany, H. Gilbert, D.W. Fong, D.C. Culver, C. Hobson, K.D. Kendall, M.A. Davis, and S.J. Taylor. 2017. Evaluation of eDNA for groundwater invertebrate detection and monitoring: a case study with endangered Stygobromus (Amphipoda: Crangonyctidae). Conservation Genetics Resources. https://doi.org/10.1007/s12686-017-0785-2

  • Carlini, D.B.*, and D.W. Fong. 2017. The transcriptomes of cave and surface populations of Gammarus minus (Crustacea: Amphipoda) provide evidence for positive selection on cave downregulated transcripts. PLoS ONE 12(10): e0186173. https://doi.org/10.1371/journal.pone.0186173

  • Bilandžija, H, M. Laslo, M.L. Porter, and D.W. Fong*. 2017. Melanization in response to wounding is ancestral in arthropods and conserved in albino cave species. Scientific Reports 7:17148. https://www.nature.com/articles/s41598-017-17471-2

  • Gowin, J, Kothmann, W.W. (2016). The Human Brain: Student's Self-Test Coloring Book. Hauppauge, NY. Barron's Educational Series.

  • Kothmann, W.W., Trexler, E.B., Whitaker, C.M., Li, W., Massey, S.C., O'Brien, J. (2012) Nonsynaptic NMDA receptors mediate activity-dependent plasticity of gap junctional coupling in the AII amacrine cell network. Journal of Neuroscience 32(20),6747-6759.

  • Paffhausen E*, Alowais Y*, Chao C, Callihan E, Creswell K, Bracht, JR. Discovery of a stem-like multipotent cell fate. American Journal of Stem Cells. In press. (* co-first authors.)

  • Lindblad KA1, Bracht, JR1, Williams AE, Landweber LF. Thousands of RNA-cached copies of whole chromosomes are present in the ciliate Oxytricha during development. RNA. 2017 April 27.

  • Bracht JR1*, Wang X1*, Shetty K, Chen X, Uttarotai G, Callihan E, McCloud S, Clay D, Wang J, Nowacki M, Landweber LF. Chromosome fusions triggered by noncoding RNA. RNA Biology. 2016 Jun 7:1-12. (1 co-first authors. * corresponding.)

  • Chen X1, Bracht JR1, Goldman A, Swart E, Dolzhenko E, Swart E, Clay D, Perlman DH, Doak TG, Stuart A, Amemiya C, Landweber LF. The architecture of a scrambled genome reveals massive levels of genomic rearrangement during development. Cell. 2014 Aug 28:158(5):1187-98. (1 co-first authors.)

  • Østbye K, Østbye E, Lien AM, Lee LR, Lauritzen SE, Carlini DB. In revision. Morphology and life history in cave and surface populations of Gammarus lacustris (L.) imply adaptation to the dark-nutrient poor cave environment.

  • Carlini DB, Makowski M. 2015. Codon bias and gene ontology in holometabolous and hemimetabolous insects. Journal of Evolutionary Zoology Part B: Molecular and Developmental Evolution 324: 686-698.

  • Tudge, C. C., Lemaitre, R. and Schneider-Paolantonio, K. (2018). Studies of male sexual tubes in hermit crabs (Crustacea: Decapoda: Anomura: Paguroidea). III. Morphology of the sexual tube in Catapagurus sharreri A. Milne-Edwards, 1880 (Paguridae). Journal of Crustacean Biology, (doi:10.1093/jcbiol/rux124).

  • Assugeni, C. O., Magalhaes, T., Bolanos, J., Tudge, C. C., Mantelatto, F. L. and Zara, F. J. (2017). Ultrastructure of the spermatozoa of spider crabs, family Mithracidae (Crustacea, Decapoda, Brachyura): Integrative analysis based on morphological and molecular data. Journal of Morphology 278: 1628-1646 (DOI: 10.1002/jmor.20737).

  • Rogers, D.C, Ahyong, S. T., Boyko, C.B, D'Udekem D'Acoz, C., et al. 2017. Images are not and should not ever be type specimens: a rebuttal to Garraffoni & Freitas. Zootaxa 4269(4): 455-459.

  • Tudge, C.C. (2016). Amir Sagi, recipient of the Crustacean Society Excellence in Research Award. Journal of Crustacean Biology 36(6): 865-866.

  • Sepahvand, V., Momtazi, F. and Tudge C.C. (2015). Cheramus iranicus, a new species of ghost shrimp (Decapoda: Axiidea: Callianassidae) from the Persian Gulf, Iran. Zootaxa 4040(2): 215-224.

  • Sepahvand, V., Sari, A., Tudge, C.C. and Bolouki, M. (2014). A study of burrow morphology of representative axiid and gebiid mud shrimps, from Persian Gulf and Gulf of Oman, Iran. Nauplius 22(2): 137-144.

  • Poore, GCB., Ahyong, ST., Bracken-Grissom, HD., Chan, T-Y., Chu, KH., Crandall, KA., Dworschak, PC., Felder, DL., Feldmann, RM., Hyzny, M., Karasawa, H., Lemaitre, R., Komai, T., Li, X., Mantelatto, FL., Martin, JW., Ngoc-Ho, N., Robles, R., Schweitzer, CE., Tamaki, A., Tsang, LM., Tudge, CC. (2014). On stabilising the names of the infraorders of thalassinidean shrimps, Axiidea De Saint Laurent, 1979 and Gebiidea De Saint Laurent, 1979 (Decapoda). Crustaceana 87(10): 1258-1272.

  • Tudge, C.C., Scheltinga, D.M., Jamieson, B.G.M., Guinot, D. and Richer de Forges, B. (2014). Comparative ultrastructure of the spermatozoa of the Majoidea (Crustacea, Decapoda, Brachyura) with new data on six species in five genera. Acta Zoologica 95(1): 1-20 (First published on-line Nov. 7, 2012, DOI: 10.1111/azo.12005).

  • Guan, C., Wu, B., Yu, T., Wang, Q., Krogan, N.T., Liu, X., and Y. Jiao (2017) Spatial auxin signaling controls leaf flattening in Arabidopsis. Current Biology 27, 2940-2950.

  • Carey, N.C. and N.T. Krogan (2017) The role of AUXIN RESPONSE FACTORs in the development and differential growth of inflorescence stems. Plant Signaling & Behavior 12, e1307492-1 - e1307492-6.

  • Krogan, N.T., Marcos, D., Weiner, A.I. and T. Berleth (2016) The auxin response factor MONOPTEROS controls meristem function and organogenesis in both the shoot and root through the direct regulation of PIN genes. New Phytologist 212, 42-50.

  • Krogan, N.T. and T. Berleth (2015) The identification and characterization of specific ARF-Aux/IAA regulatory modules in plant growth and development. Plant Signaling & Behavior 10, e992748-1-e992748-4.

  • Krogan, N.T., Yin, X., Ckurshumova, W. and T. Berleth (2014) Distinct subclades of Aux/IAA genes are direct targets of ARF5/MP transcriptional regulation. New Phytologist 204, 474-483.

  • Chow, B.Y., Sanchez, S.E., Breton, G., Pruneda-Paz, J.L., Krogan, N.T., and S.A. Kay (2014) Transcriptional regulation of LUX by CBF1 mediates cold input to the circadian clock in Arabidopsis. Current Biology 24, 1518-1524.

  • KAPLAN JB, Sampathkumar V, Bendaoud M, Giannakakis AK, Lally ET, Balashova NV. 2016. In vitro characterization of biofilms formed by Kingella kingae. Molecular Oral Microbiology doi: 10.1111/omi.12176 [Epub ahead of print].

  • Weiser J, Henke H, Hector N, Both A, Christner M, Büttner H, KAPLAN JB, Rohde H. 2016. Sub-inhibitory tigecycline concentrations induce extracellular matrix binding protein Embp dependent Staphylococcus epidermidis biofilm formation and immune evasion. International Journal of Medical Microbiology 306:471-478.

  • Mlynek KD, Callahan MT, Shimkevitch AV, Farmer JT, Endres JL, Marchand M, Bayles KW, Horswill AR, KAPLAN JB. 2016. Effects of low-dose amoxicillin on Staphylococcus aureus USA300 biofilms. Antimicrobial Agents and Chemotherapy 60:2639-2651.

  • Shanmugam M, Gopal P, ElAbbar F, Schreiner HC, KAPLAN JB, Fine DH, Ramasubbu N. 2015. Role of exopolysaccharide in Aggregatibacter actinomycetemcomitans-induced bone loss in a rat model for periodontal disease. PLoS ONE 10:e0117487.

  • Farmer JT, Shimkevitch AV, Reilly PS, Mlynek KD, Jensen KS, Callahan MT, Bushaw-Newton KL, KAPLAN JB. 2014. Environmental bacteria produce abundant and diverse antibiofilm compounds. Journal of Applied Microbiology 117:1663-1673.

  • Chabane YN, Marti S, Rihouey C, Alexandre S, Hardouin J, Lesouhaitier O, Vila J, KAPLAN JB, Jouenne T, Dé E. 2014. Characterisation of pellicles formed by Acinetobacter baumannii at the air-liquid interface. PLoS ONE 10:e111660.

  • Ng M, Epstein SB, Callahan MT, Piotrowski BO, Simon GL, Roberts AD, Keiser JF, KAPLAN JB. 2014. Induction of MRSA biofilm by low-dose β-lactam antibiotics: specificity, prevalence and dose-response effects. Dose-Response 12:152-161.

  • KAPLAN JB. 2014. Biofilm matrix-degrading enzymes, pp. 203-213. In Microbial Biofilms - Methods and Protocols, Donelli G, (ed.). Humana Press, Springer Publishing Group, New York, N.Y.