Albert Cheh Prof Emeritus Environmental Science
- Degrees
- PhD, Biochemistry, University of California, Berkeley BA, Chemistry, Columbia
- Bio
- My research focuses on signatures of exposure to environmental carcinogens. I have also studied the enzymatic digestion of biomass to produce cellulosic ethanol biofuel, error-prone bypass DNA polymerase action at polycyclic aromatic hydrocarbon diol epoxide (PAH-DE) induced damage sites, PAH-DE reactions with DNA, water chlorination mutagens and toxic heavy metals. I teach courses about our energy system and its relationship to climate change.
- See Also
- Environmental Science
- Cheh's Homepage
- Chemistry Department
- For the Media
- To request an interview for a news story, call AU Communications at 202-885-5950 or submit a request.
Partnerships & Affiliations
Scholarly, Creative & Professional Activities
Research Interests
Mechanisms by which polycyclic aromatic hydrocarbon carcinogens found in cigarette and other smoke, and soot damage DNA and cause mutations and cancer. Bypass DNA synthesis by Y-family DNA polymerases. Enzymatic digestion of lignocellulose in the production of cellulosic ethanol.
Honors, Awards, and Fellowships
- NIH Postdoctoral Fellowship Award, 1F32 ES05091, 1977-78
- American University Award for Outstanding Teaching in the General Education Program, 2004
Selected Publications
- Chiapperino, D., Kroth, H., Kramarczuk, I. H., Sayer, J. M., Masutani, C., Hanaoka, F., Jerina, D. M. and Cheh, A.M.* Preferential Misincorporation Of Purine Nucleotides By Human DNA Polymerase Eta Opposite Benzo[A]Pyrene 7,8-Diol 9,10-Epoxide Deoxyguanosine Adducts” J. Biol. Chem. 277, 11765-11771 (2002).
- Chiapperino, D., Cai, M., Sayer, J. M., Yagi, H., Kroth, H., Masutani, C., Hanaoka, F., Jerina, D. M. and Cheh, A.M.* “Error-prone Translesion Synthesis with DNA Polymerase Eta on DNA Containing 7,8-Dihydroxy-9,10-Epoxy-7,8,9,10-Tetrahydrobenzo[a]pyrenyl dA Adducts” J. Biol. Chem. 280, 39684-39692 (2005).
- Chundawat, S. P.S.*, Bellesia, G., Uppugundla, N., da Costa Sousa,L., Gao,D., Cheh, A.M., Agarwal, U.P., Bianchetti, C.M., Phillips, G.N., Jr., Langan,P., Balan,V., Gunanakaran,S*. and Dale, B.E. Restructuring the Crystalline Cellulose Hydrogen Bond Network Enhances Its Depolymerization Rate, J. Amer. Chem Soc. 133 (29), 11163–11174 (2011)
• *corresponding author
Work In Progress
- He,Y.J., Yagi, H. Jerina, D. M.and Cheh, A. M.* Cytosine Methylation of CpG Increases Yield Of Benzo[c]phenanthrene Diol Epoxide Adducts at Adjacent A and Dibenz[a,j]anthracene Diol Epoxide +2 Adducts at G.
- Cai, M., Sayer, J.M., Ohashi, E., Ohmori, H., Jerina, D.M. and Cheh, A.M.* “Limited Error-prone Bypass of Benzo[a]pyrene 7,8-Diol 9,10-Epoxide DE-2 Deoxyadenosine Adducts by Human DNA Polymerase Kappa
- Phillips, T. B., Cai, M., Sayer, J. M., Masutani, C., Hanaoka, F., Jerina, D. M. and Cheh, A.M.*, “Unusual rate acceleration of extension by DNA polymerase Eta at Benzo[c]phenanthrene Diol Epoxide dA adducts” *corresponding author